Reengineering Blood Clotting With Bispecific Antibodies

Emicizumab, a bispecific antibody that bridges clotting factors IX and X, restores factor VIII function and prevents bleeding in hemophilia A with infrequent injections.

The Genome’s Hidden Layer

A study finds that mammalian cells can join RNA from separate genes into functional hybrid proteins, revealing a hidden layer of genome complexity in immune cells.

Rare Genetic Mutation Linked To 25-Fold Higher Lung Cancer Risk

The inherited mutation substantially increases the chance of developing lung cancer, including in people who don’t smoke.

New Treatment Reduces Women’s Osteoporosis Fractures By 94%

A one-time infusion of sugar-tagged bone marrow cells cut fragility fractures 94% in an osteoporosis trial, pointing toward a potential bone-regeneration treatment.

More Young Children Are Taking GLP-1 Drugs. What Parents Should Know

GLP-1 prescriptions are soaring for younger children despite the medications not being approved for this age group. Are they safe and effective in these children?

U.S.-U.K. Deal To Raise Drug Prices In Britain Faces Major Challenges

NHS hasn’t budgeted for the spending increase entailed by the U.S.-U.K. deal to allow payment for more drugs while keeping funding levels constant for other healthcare.

Trump’s Medicare Models To Lower Drug Prices Won’t Deliver Projected Cost Savings

The Trump administration has made bold claims about how much GLOBE and GUARD models will save Medicare. But most of those vanish once the exemptions are accounted for.

As Most Favored Nation Drug Price Deals Stay Secret, Burning Questions Remain

By remaining shrouded in mystery, the MFN deals agreed to with drug makers reveal too little to tell how much money they’ll save governments as well as taxpayers and patients.

A Simpler Way To Build Antibody Cancer Drugs

A new two-step method makes more uniform antibody-drug conjugates by attaching cancer drugs at a precise antibody site, simplifying targeted cancer drug development.

A New Drug Takes Aim At One Of Cancer’s Most Difficult Targets

FDA-approved daraxonrasib targets RAS in metastatic pancreatic cancer, doubling median survival versus chemotherapy and delivering a long-awaited treatment advance.